Hurel

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Hurel logo

Hurel logo

Board members

Robert M. Freedman

Robert M. Freedman

Chairman | Chief Executive Officer

James S. MacDonald

James S. MacDonald

Director

Eric Novik

Eric Novik

Chief Scientific Officer

Martin L. Yarmush

Martin L. Yarmush

Chief Scientific Adviser

Matthew K. Shipton

Matthew K. Shipton

Head of sales and marketting

Short Description

Originates from Schering-Plough Research Institute (now Merck & Co) and Cornell University, HµREL® Corporation (“Hurel”) is a privately held bioanalytic tools company with corporate headquarters and laboratories situated in North Brunswick, New Jersey, USA. HµREL® researches, develops, and commercializes products and services based on its patent-pending three-dimensional (“3D”) cell-based tissue constructs comprised of primary (i.e., actual) cells of the human or other species; as well as its patented microfluidic devices that further enhance the already high functionality and range of application of its cell-based in vitro models. At the present time Hurel offers hepatic co-culture models of the human, dog and rat species; hepatic models of mouse and non-human primate are under development.

Hurel location

Hurel location

Products

Hurel commercialized plate pre-loaded with several cell types (either co-culture plate or multi-species plate). They also sell kits for the detection of biliary efflux capabilities, acute and repeated toxicity measurement. Regarding Organ-on-a-Chip, they commercialized microfluidic platforms (Beta test) allowing fluidic interconnection between several cell-based models.

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Noticeable publications

-Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans, Applied Pharmacology, 2014

-Design and Application of Microfluidic Systems for In Vitro Pharmacokinetic Evaluation of Drug Candidates, Current Drug Metabolism, 2009

-A Microfluidic Hepatic Coculture Platform for Cell-based Drug Metabolism Studies, Biochem Pharmacol, 2009

-Evaluation of a microfluidic-based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human, Biochem Pharmacol, 2009

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