Sophie Lelièvre

Sophie Lelièvre

Sophie Lelièvre

Biography 

Dr. Sophie Lelièvre is a native of France who obtained her undergraduate degree as engineer in Veterinary Sciences from the University of Louvain (Belgium) and her D.V.M. degree from the University of Liège (Belgium) in 1990. She worked as a veterinarian in the emergency room in Paris area (France) from 1990 to 1995, while pursuing M.S. and Ph.D. graduate studies in Cancer Pharmacology at the Gustave Roussy Cancer Institute and University of Paris VI (Pierre & Marie Curie). Dr. Sophie Lelièvre is the 1995 recipient of (i) the National Prize for Fundamental Cancer Research/young investigator from the French Society of Cancer and National Federation of Cancer Institutes and (ii) the National Alexandre Joel Prize for young investigator from the Association for Cancer Research. During her postdoctoral training in Mina Bissell’s laboratory at the Lawrence Berkeley National Laboratory (USA) from 1995 to 2000, she studied the role of the organization of the cell nucleus in normal and cancerous breast epithelial cell behaviors using three-dimensional models of cell culture that recapitulate tissue organization.

Sophie Lelièvre research accomplishments include notably, (i) the development of methods to analyze and detect phenotypes based on cell nucleus organization at the single cell level, (ii) the design of preclinical three-dimensional (3D) cell culture models including organs-on-a-chip to be used for screening protective agents against breast cancer development and for the design of nanomedical tools for therapies, and (iii) the identification of early breast tissue alterations necessary for cancer development and related new potential targets for breast cancer prevention and treatment. In 2015, she created the 3D Cell Culture Core (3D3C) Facility at Purdue University with the aim of bringing engineers and biologists together to design better models for research on chronic diseases.

Education:

2008 – LL.M. (PH) | University of Rennes I, France

1994 – PhD | University of Paris VI, France

1991 – MS | University of Paris VI, France

1990 – Medical | University of Liege, Belgium

1987 – Engineer | University of Louvain, Belgium

Representative Publications:

– Vidi P-A, Ling L, Lelièvre SA, Irudayaraj PJ. Nanoscale histone localization in live cells reveals reduced chromatin mobility in response to DNA damage. J Cell Sci. 128:599-604, 2015

– Bazzoun D, Lelièvre SA, Talhouk R. “Beyond the channel: Role of connexins in regulating normal and cancerous processes in the mammary gland.” In Intercellular Communication in Cancer, Springer (In press)

– Weaver C, Teegarden D, Hwalla N, Welch A, Lelièvre SA. International Breast Cancer and Nutrition: A model for research, training, and policy in diet, epigenetics, and chronic disease prevention. Adv Nutr. 5:566-7, 2014.

Lelièvre SA. Taking a chance on epigenetics, (opinion article) Front. Genet. 2014

– Vidi PA, Liu J, Jayaraman S, Dorfman G, Salles D, Gray M, Abad P, Moghe PV, Irudayaraj JMK, Wiesmüller L, and Lelièvre SA. The Nuclear Mitotic Apparatus Protein, NuMA, controls the presence of the ISWI ATPase SNF2h at DNA Breaks. Nucleic Acids Research, 42:6365-79, 2014.

– Hodges KB, Bazzoun D, McDole K, Talhouk R and SA Lelièvre. The role of Epigenetics in Mammary Gland Development and Breast Cancer Risk, In Mammary Glands: Anatomy, Development, and Diseases, Ed. E. Rucker, Series ‘Veterinary Sciences and Medicine’, Chapter IV, pp 63-112, 2014, Nova Science Publishers, Inc., New York

– Vidi PA, Maleki T, Ochoa M, Wang L, Clark SM, Leary JF, Lelièvre SA. Disease-On-Chip: Mimicry of Tumor Growth in Mammary Ducts. Lab on chip, 14:172-7, 2014.

Lelièvre SA and CM. Weaver. Global Nutrition Research: Nutrition and Breast Cancer Prevention as a Model. Nutrition Rev, 71: 742–752, 2013

– Vidi PA, Leary JF, Lelièvre SA. Building risk-on-a-chip models to improve breast cancer risk assessment and prevention, Frontier Review, Integr Biol (Camb). 5:1110-8, 2013.

– Leary JF, Key J, Vidi P-A, Cooper CL, Kole A, Reece LM, Lelièvre SA. Human organ-on-a-chip BioMEMS devices for testing new diagnostic and therapeutic strategies. Microfuildics, BioMEMs, and Medical Microsystems XI, Proc. of SPIE, 8615:86150A, 2013

– Bazzoun D, Lelièvre SA, Talhouk R. Polarity proteins as regulators of cell-cell junctional complexes: Implications for breast cancer. Pharmacol Ther. 138:418-27, 2013

– Vidi P-A, MJ Bissell, and SA Lelièvre. “Three-dimensional culture of human breast epithelial cells: The how and the Why”. Epithelial Cell Culture, Methods in Mol Biol, 945:193-219, 2013

– McDole K and Lelièvre SA. Comparative Oncology to understand mammary cancer heterogeneity; Editorial, the Veterinary Journal 194:3-4, 2012

– Yue S, J Cardenas-Morà, LS Chaboub, SA Lelièvre and J-X Cheng. Label-free analysis of tissue polarity in live three-dimensional culture of breast epithelial cells using Raman spectroscopy. Biophys J 102:1215-23, 2012

– Teegarden D, I Romieu, and SA Lelièvre. “Redefining the impact of nutrition on breast cancer incidence: Is epigenetics involved?” Nutrition Research Reviews 25:68-95, 2012

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