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TissUse logo

TissUse logo

Board members

Uwe Marx

Uwe Marx

Chief Executive Officer

Revk Horland

Revk Horland

VP Business Development

Silke Hoffmann

Silke Hoffmann

VP intellectual property & innovation

Short Description

Originate from the Technische Universität Berlin, and created in 2010, TissUse is a Berlin, Germany-based, vibrant growth company who has developed a unique “Multi-Organ-Chip” platform that – for the first time ever – provides preclinical insight on the systemic level using human tissue. This enabling technology platform consists of a miniaturized construct that closely simulates the activity of multiple human organs in their true physiological context. TissUse‘s Multi-Organ-Chips provide a completely new approach to predict, for example, toxicity, ADME profiles and efficacy in vitro, reducing and replacing laboratory animal testing and streamlining human clinical trials.

TissUse is additionally applying its platform and know-how to develop spin-off programs in a variety of tissue and organ repair areas starting with the cosmetic market of hair transplants.

TissUse location

TissUse location

Products

TissUse already commercialized interconnected organ-chip solutions (2 and 4 organs). They also developed their own fluidic control  unit. TissUse offers high-value service contracts to create custom solutions for safety evaluation of drugs, cosmetics and chemicals, and pre-clinical human disease modelling. Any new chip design serving customer needs with a specific organ arrangement can be prototyped and produced at short notice due to a proprietary rapid prototyping procedure established at TissUse. The versatile TissUse approach addresses multiple organs & tissues to make the right chip for the right assay.

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Noticeable publications

-2015, Lab on a Chip, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

-2017, Front. Bioeng. Biotechnol., Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices

-2015, European Journal of Pharmaceutics and Biopharmaceutics, Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

-2015, Journal of Visualized Experiments, The Multi-organ Chip – A Microfluidic Platform for Long-term Multi-tissue Coculture

-2013, Lab on a Chip, Integrating biological vasculature into a multi-organ-chip microsystem

-2013, Lab on a Chip, Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

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