The fastest heater & cooler for live-cell imaging

We developed the world’s fastest heater-cooler for microscopy. It enables ultra-fast temperature shifts [10 seconds] from any temperature to any other in the 5-45°C range. CherryTemp fits any inverted microscope. You can now control in real-time your favorite molecular processes, observe dynamic events linked to temperature on live and discover unthought mechanisms.


CherryTemp features…

BELOW AMBIANT | 5 TO 45°C

Heat and cool down your samples in the 5 to 45°C range

ULTRAFAST SHIFTS | 10 SECONDS

Shift in less than 10 seconds  from any temperature to any other in the 5 to 45°C range

STABLE & PRECISE | 0.1°C

Long-term stability and 0.1°C precision ensured

FITS ANY INVERTED MICROSCOPE

CherryTemp can be easily installed and shared between different inverted microscopes. We have a set of ergonomic elements fitting main brands (Nikon Ti Eclipse, Zeiss AxioObserver, Olympus IX81, Leica DMI 4000/6000…).

USER FRIENDLY

Get all in one pack, set up the system and start immediately!

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Change the temperature of your sample within seconds during live-cell imaging

Initially developed for PCR military application, the world fastest temperature controller for microscopy is now available for live-cell imaging.

One-clic change from any temperature to anyother in the 5 to 45°C range in less than 10 seconds with long-term stability and 0.1°C precision.

Benefit from robust and precise temperature calibration. Our software continuously integrates changes of your room temperature. It also takes into account the heat sink played by immersion objective lenses.

From cells to observation in 30 seconds

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HOW IT WORKS : TAKE A TOUR

Easy & intuitive interface

The intuitive CherryTemp software interface enables you to track thermally sensitive dynamic cellular processes with high-resolution imaging. Set and modify the temperature in the 5 to 45°C range in one click.

Keep focusing on your observation.

Standard mounting of samples

Use your usual sample preparation protocol. We provide a universal insert to fit on your stage and a simple and efficient mounting system compatible with standard cover clips.

Get your cells ready for observation in less than 30 seconds.

Ultrafast temperature shifts

We provide two independent temperature channels to enable fast and stable temperature changes. They are powerful and provide seemless heating and cooling in the 5-45°C range, yet their tiny size enables integration in any existing inverted microscopy setup.

Change temperature in less than 10 seconds, regardless of the delta between temperatures.

High temperature precision

The CherryTemp electronic controller is the core of the system. The electronic regulation and silent chillers are keys for a stable and precise temperature control.

You get a +/- 0.1°C stability for hours within the 5-45°C range.

Seemless fluid actuation

No hassle with long lasting experiments thanks to our closed loop fluid actuation system. This fine tuned fluidic controller pumps thermalized fluid through the system. The flow rate is stable and optimized for real time temperature control.

You get an unprecedented temperature control of your cells.

First installation in 20 minutes

You want to focus on your experimentation this is why we’ve made CherryTemp easy to install.

CherryTemp is plug and play and comes along with a didactic installation guide.

No interference with your set-up

Your microscope set-up can already be complex this is why we’ve designed CherryTemp to ensure smooth integration.

Installation and disposition of CherryTemp is easy and flexible.

Fits any inverted microscope

You might want to use different microscopes, this is why we’ve designed CherryTemp to be compatible with any inverted microscope.

Smart mounting of your cells

If you want a special design for your cells, contact our expert team. We’ve worked to design smart solutions as we believe simplicity is a strength.

Our mounting systems offers a large scale of applications and high flexibility for live-cell imaging.

Easy to use

Change temperature in one click and simply input temperature settings on CherrySoft.

We’ve thought our software based on scientists’ feedback as we pay attention not to add complexity to your experimentation.

We are experts & here

We’ve set-up our processes customer-centered as we want to make you happy using CherryTemp.

We’ve built an expert team to lead live-cell imaging dynamic control, get in touch and benefit from our strong skills.

Watch a real time infra-red movie of our temperature controller

Unprecedented temperature shifts

Benefit from great advantages

temperature-control-microscopy-one-clic-3Monitor the thermalization of your cells in real time

The Cherry Temp platform was developed to enable real time change and monitoring of your sample temperature. Thanks to the unique calibration scheme integrated into the platform, the system is able to adapt  in real time the temperature of your cell when it detects any change in the microscope environment which may affect you sample temperature. Learn more

temperature-heater-cooler-nikon-ti

Install the CherryTemp system on different microscopes in 10 minutes

CherryTemp has been designed to fit all major microscope brands (Leica, Nikon, Olympus and Zeiss). If you use shared microscope CherryTemp can be installed and uninstalled from your microscope in less than 10 minutes.

temperature-control-microscopy-immersion-objectiveKeep our unprecedented precision with both air and immersion objective lenses

The confinement of the sample as well as the very short thermal path frees our technologies almost completely from the influence of classical thermal disruptive parameters. This unique structure coupled to our real time calibration scheme enable us to guarantee temperature homogeneity of your cells even with immersion objectives. Learn more

temperature-heater-cooler-precise-2Ensure temperature stability and homogeneity with a 0.1°C precision

The very short thermal path between sample and thermal fluid frees our technologies almost completely from the influence of classical thermal disruptive parameters.This unique structure coupled to our real time calibration scheme enable them to guarantee temperature stability of your cell sample below 0.5°C.   Learn more

temperature-control-microscopy-one-clic-4One-click change the temperature of your cells

Cherry Temp software enables you to change the temperature of your cells during live imaging in one click. You can also set temperature cycle for long or overnight experiment. We designed the software to be as easy to use as a PCR system.

temperature-heater-cooler-stage-2Forget incubation box, clean your set-up and get an easy access to your sample

Cherry Temp is a platform which fits to your microscope similarly to a top-stage incubator. It enables you to easily access your biological sample at any moment. Moreover, with its large 5-45°C range and intelligent calibration, it is self-sufficient: no more incubation boxe nor objective collar are necessary. Learn more

Publications

Fast temperature control for thermosensitive protein regulation (Developmental cell, 2009)

The spindle midzone—composed of antiparallel microtubules, microtubule-associated proteins (MAPs), and motors—is the structure responsible for microtubule organization and sliding during anaphase B. Read more →

Fast microfluidic temperature control for high resolution live cell imaging (Lab on Chip, 2011)

One major advantage of using genetically tractable model organisms such as the fission yeastSchizosaccharomyces pombe is the ability to construct temperature-sensitive mutations in a gene. Read more →

Fast temperature regulation for mitochondria positioning on microscope (Current Biology, 2011)

Mitochondria form a dynamic tubular network within the cell. Proper mitochondria movement and distribution are critical for their localized function in cell metabolism, growth, and survival. Read more →

Fast temperature regulator for cytoskeleton studies on microscope (Methods in Cell biology, 2010)

Recent development in soft lithography and microfluidics enables biologists to create tools to control the cellular microenvironment. One such control is the ability to quickly change the temperature of the cells. Read more →

Ultrafast, sensitive and large-volume on-chip real-time PCR (Lab on Chip, 2016)

An ultrafast, sensitive and large-volume real-time PCR system based on microfluidic thermalization. The method is based on the circulation of pre-heated liquids in a microfluidic chip that thermalize the PCR chamber… Read more →

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