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BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore
In the publication Edwards F. et al. (eLife 2018), the authors decipher several molecular mechanisms governing chromosome segregation in C. elegans embryo. The kinase ...
Read moreFLIRT: fast local infrared thermogenetics for subcellular control of protein function
FLIRTing with temperature at the subcellular level In the publication FLIRT: fast local infrared thermogenetics for subcellular control of protein function (Hirsch SM. et al. ...
Read moreTransfection In Perfused Microfluidic Cell Culture
Transfection In Perfused Microfluidic Cell Culture In this paper, William Raimes and colleagues compared the efficiency of transfection between cells with continuous perfusion and cells ...
Read moreLive-cell and perfusion: weak protein-protein interactions
Summary | Weakly bound protein complexes play a crucial role in metabolic, regulatory, and signaling pathways, due in part to the high tunability of ...
Read moreNuclear import receptor inhibits phase separation of FUS through binding to multiple sites
FUS Liquid-Liquid Phase Separation Cellular compartmentalization is essential for cell homeostasis. Cytoplasmic compartments can be delineated by molecular concentrates or condensates, generated by the physical ...
Read moreC. elegans oocytes & chromosome segregation: microtubule pushing
(Nature Communications, 2017) In her paper, Kim Laband (from Julien Dumont's lab), studied the mechanism of meiotic chromosome segregation in C. elegans oocytes. Among different techniques, high-resolution microscopy ...
Read moreInhibition of microtubule assembly using fast temperature changes
(Development, 2017) Summary | In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation – essential to prevent miscarriage or developmental defects – ...
Read moreA drug-compatible and temperature controlled microfluidic device for live-cell imaging
(Open Biology, 2016) Summary | Monitoring cellular responses to changes in growth conditions and perturbation of targeted pathways is integral to the investigation of biological processes. ...
Read moreAn easy-to-build and re-usable microfluidic system for live-cell imaging
Summary | Background Real-time monitoring of cellular responses to dynamic changes in their environment or to specific treatments has become central to cell biology. However, when ...
Read moreReal-time qPCR using CherryTemp on-a-chip
(Lab on Chip, 2016) Summary | To control future infectious disease outbreaks, like the 2014 Ebola epidemic, it is necessary to develop ultrafast molecular assays enabling ...
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