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Cultivating gut microbiota on a gut-on-a-chip
A complex human gut microbiome cultured in anaerobic intestine-on-a-chip A recently published paper on Nature biomedical engineering highlights the possibility of cultivating gut microbiota on ...
Read moreTumor Hypoxia and metastasis
Solid tumors are characterized by areas of hypoxic tissue heterogeneously distributed inside the tumor mass. Hypoxia triggers tumor aggressivity, as it tends to select ...
Read more3D cell culture and anticancer drug testing
Efficacity and toxicity of candidate anticancer drugs has been assessed on 2D cell culture models over the past few decades. This model has allowed ...
Read moreTumor microenvironment (TME)
The tumor microenvironment (TME) is a complex biochemical network which includes multiple factors surrounding tumor cells, such as vascular networks, the extracellular matrix (ECM), ...
Read moreIn Vitro Immune Organs-on-Chip for Drug Development
A drug should pass the preclinical evaluation phase to be FDA approved. This relies (i) on in vitro cell culture platforms and (ii) on ...
Read moreCheckpoint modulation – A new way to direct the immune system against renal cell carcinoma
Immune checkpoint modulation in renal cell carcinoma In this paper, Bedke and colleague highlight the way that patients treated for the metastatic disease in renal cell carcinoma (mRCC) by ...
Read moreImmune Checkpoint Modulators: An Emerging Antiglioma Armamentarium
Immune Checkpoint Modulators as an emerging therapy Through this paper, Kim and colleagues highlight the way that immune checkpoint modulators are exploited by tumor cells ...
Read moreImmune Check Point Modulator in cancer therapy
Immune Checkpoint modulators https://www.youtube.com/watch?v=iH1QUMwEI3U Check Point modulator validation system dedicated system to cell-cell interactions follow-up Summary | Immune Checkpoint modulators are new promising therapies that specifically target the ability ...
Read moreImmuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity
Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity In this paper, Anagnostou and colleagues "discuss endpoints used in I-O trials to date and potential optimal endpoints for ...
Read moreThe Challenge for Development of Valuable Immuno-oncology Biomarkers
The Challenge for Development of Valuable Immuno-oncology Biomarkers. In this paper, Mehnert JM and colleagues discussed the new advances in immuno-oncology and related biomarkers identification challenges. ...
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