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FULLY DIFFERENTIATED SKIN ON CHIP
Reijnders CMA,...Gibbs S, Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts, Tissue Eng Part A. 2015 Sep 1; ...
Read moreLIVER BIOPSY ON CHIP
AIMS → Increase biopsies viability in long term culture → Imaging and biochemical quantification of drug effect → Interface blood vessel/hepatocyte → DILI assessment based on biochemical marker and morphometric read-out FEATURES → ...
Read moreSPHEROID HUMAN KIDNEY CANCER ON CHIP
AIMS → Characterization and quantification of antimigration and antiproliferative effects of several molecules, mimicking acute exposure. → Detection of specific biomarkers FEATURES → Temperature : 37°C → Gas : normoxia 5% CO2 → Perfusion ...
Read moreHUMAN BIOPSIES CULTURE
AIMS → Tumor(s) cells sequential exposure to compounds in different wells (drugs, antibodies, reagents) → Maintain automatic perfusion at a constant flow rate → Live optical readouts acquisition (fluorescence) FEATURES → Temperature ...
Read moreLONG TERM KIDNEY TISSUE CULTURE
AIMS → Human kidney culture for 7 days → Automatic perfusion at a flow rate → Live optical readouts acquisition (fluorescence) FEATURES → Temperature : 37°C → Gas : normoxia, 5% CO2 → Perfusion mode : pulse → Culture ...
Read more3D cell culture and anticancer drug testing
Efficacity and toxicity of candidate anticancer drugs has been assessed on 2D cell culture models over the past few decades. This model has allowed ...
Read moreLiver function and liver on a chip
Liver is a fundamental organ for human life. It is responsible for macromolecules (carbohydrates, fats, protein) metabolization and the detoxification of our blood as ...
Read moreAre spheroids recapitulating basic physiology of human organs?
Spheroids, as a good universal organ model ? Recent advances in bioengineering of cells, tissue coupled with the newly identified need of more physiologically relevant ...
Read moreThe complexity behind the 3D cell cultures: the 3D liver cell culture case
Introduction to 3D Liver Cell Culture Once it is clear how to deal with 3D cell cultures it is time to focus on one type ...
Read moreFrom 2D to 3D cell cultures
Why and how? From 2D to 3D cell culture: The main issues find while using 2D cell systems, is that it is not possible to have ...
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