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This review is related to medium injection and medium perfusion solutions for microfluidics. It explains differents methods and techniques (active and passive) as an introduction to perfusion for live cell imaging.
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Passive medium injection techniques in microfluidics
Capillary forces
Capillary effects are key forces at small scales, in the range of millimeters to micrometers. They are present when one liquid is in contact with any other gas, liquid or solid. That contact or interface rich to a surface tension which is the force created between both surfaces of the different components when they get in touch. The creation of a new interface has a cost of energy that can be expressed in the following equation: E=σA. Where σ is the surface tension measured in N/m while the A is the area of the interface or contact between the two components and E is the force created. As an example, surface tension is the reason why liquid droplets are spherical because they tend to reduce their surface to reduce the forces needed to be stable (1).
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Medium Perfusion Pack
dedicated system to living cells
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The full content has been moved to our new website. Follow the link below to get full access.
https://innovation.cherrybiotech.com/organs-on-a-chip/medium-injection-an-perfusion-solutions-for-microfluidics
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Discover our Medium Perfusion system
Long-term medium perfusion, change and drug injection
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Bibliography/Sources
1.Roman B, Bico J, Adamson A W GAP, de Gennes P G B-WFQD, J MM, H MCH and HC, et al. Elasto-capillarity: deforming an elastic structure with a liquid droplet. J Phys Condens Matter [Internet]. 2010 Dec 15 [cited 2017 Jan 20];22(49):493101.
2.Neukirch S, Antkowiak A, Marigo J-J. Soft beams: When capillarity induces axial compression. Phys Rev E [Internet]. 2014 Jan 2 [cited 2017 Jan 20];89(1):12401.
3.Extrand C, Moon S. Repellency of the lotus leaf: contact angles, drop retention, and sliding angles. Langmuir [Internet]. 2014 [cited 2017 Jan 20];
4.Yamada H, Yoshida Y, Terada N, Hagihara S, Komatsu T, Terasawa A. Fabrication of gravity-driven microfluidic device. Rev Sci Instrum [Internet]. 2008 Dec [cited 2017 Jan 20];79(12):124301.
5.Intravenous Medication Administration: What to Know from HealthLine.
6.Allen JS, Lee SH, Chang ST, Choi Y-K, Friedrich C, Choi CK. A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping. Biomicrofluidics [Internet]. 2014 Jul [cited 2017 Jan 23];8(4):44116. Available from: http://aip.scitation.org/doi/10.1063/1.4892894
7.Sachan VK, Singh AK, Jahan K, Kumbar SG, Nagarale RK, Bhattacharya PK. Development of Redox-Conducting Polymer Electrodes for Non-Gassing Electro-Osmotic Pumps: A Novel Approach. J Electrochem Soc [Internet]. 2014 Oct 25 [cited 2017 Jan 23];161(13):H3029–34.
8.Slouka Z, Senapati S, Chang H-C. Microfluidic Systems with Ion-Selective Membranes. Annu Rev Anal Chem [Internet]. 2014 Jun 12 [cited 2017 Jan 23];7(1):317–35.
9.Byun CK, Abi-Samra K, Cho Y-K, Takayama S. Pumps for microfluidic cell culture. Electrophoresis [Internet]. 2014 Feb [cited 2017 Jan 23];35(2–3):245–57.
10.Nightingale AM, Beaton AD, Mowlem MC. Trends in microfluidic systems for in situ chemical analysis of natural waters. Sensors Actuators, B Chem [Internet]. 2015;221:1398–405.
11.Lagerström ME, Field MP, Séguret M, Fischer L, Hann S, Sherrell RM. Automated on-line flow-injection ICP-MS determination of trace metals (Mn, Fe, Co, Ni, Cu and Zn) in open ocean seawater: Application to the GEOTRACES program. Mar Chem. 2013;155:71–80.
12.Seo K-S, Lee K, Shim Y, Kim A, Jeon E, An S, et al. Smart syringe pumps for drug infusion during dental intravenous sedation. J Dent Anesth Pain Med [Internet]. 2016 [cited 2017 Jan 30];16(3):165.[/vc_column_text][/vc_column][vc_column width=”1/3″][vc_team title=”Written by Pablo Salaverria” subtitle=”PHD STUDENT | INNOVATION UNIT | H2020-MSCA-ITN-DIVIDE” image=”7377″]
Pablo is part of the H2020-MSCA-ITN-ETN-DivIDe European network. LEARN MORE.
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