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Fast temperature controller for live-cell imaging cytoskeleton studies

(Methods in Cell biology, 2010)

Summary | Recent development in soft lithography and microfluidics enables biologists to create tools to control the cellular microenvironment. One such control is the ability to quickly change the temperature of the cells. Genetic model organism such as fission yeast has been useful for studies of the cell cytoskeleton. In particular, the dynamic microtubule cytoskeleton responds to changes in temperature. In addition, there are temperature-sensitive mutations of cytoskeletal proteins. We describe here the fabrication and use of a microfluidic device to quickly and reversibly change cellular temperature between 2°C and 50°C. We demonstrate the use of this device while imaging at high-resolution microtubule dynamics in fission yeast.

LEARN MORE | Chapter 11 – A Fast Microfluidic Temperature Control Device for Studying Microtubule Dynamics in Fission Yeast

Cherry Temp system for Cytoskeleton

Temperature control during live-cell imaging experiments on cell mechanics and the cytoskeleton

We developped the world’s fastest heater-cooler for microscopy.
It enables ultra-fast temperature shifts [10 seconds] from any temperature to any other in the 5-45°C range.

CherryTemp fits uprights ad inverted microscopes.
Now you can image and control the temperature during  cell mechanics and cytoskeleton experiments.


Dynamic & fast : 10 seconds temperature shifts


Stable & Precise : Long term stability


Inverted & Upright scopes : Custom elements for a perfect integration


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Heat and cool down your samples in the 5 to 45°C range

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mCherry-tag C. elegans thermosensitive embryo mutants (CYK-4 ts) examined under the microscope with a CherryTemp platform.

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