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Imaging of mitochondria positioning using fast temperature regulation

(Current Biology, 2011)

Summary | Mitochondria form a dynamic tubular network within the cell. Proper mitochondria movement and distribution are critical for their localized function in cell metabolism, growth, and survival. In mammalian cells, mechanisms of mitochondria positioning appear dependent on the microtubule cytoskeleton, with kinesin or dynein motors carrying mitochondria as cargos and distributing them throughout the microtubule network. Interestingly, the timescale of microtubule dynamics occurs in seconds, and the timescale of mitochondria distribution occurs in minutes. How does the cell couple these two time constants?

LEARN MORE  | mmb1p Binds Mitochondria to Dynamic Microtubules

More publications

C. elegans oocytes & chromosome segregation: microtubule pushing

C. elegans oocytes & chromosome segregation: microtubule pushing

(Nature Communications, 2017) In her paper, Kim Laband (from Julien Dumont's lab), studied the mechanism of meiotic chromosome segregation in C. elegans oocytes....
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Inhibition of microtubule assembly using fast temperature changes

Inhibition of microtubule assembly using fast temperature changes

(Development, 2017) Summary | In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation – essential to prevent...
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Medium renewal and temperature control for live-cell imaging

Medium renewal and temperature control for live-cell imaging

(Open Biology, 2016) Summary | Monitoring cellular responses to changes in growth conditions and perturbation of targeted pathways is integral to...
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Real-time qPCR using CherryTemp on-a-chip

Real-time qPCR using CherryTemp on-a-chip

(Lab on Chip, 2016) Summary | To control future infectious disease outbreaks, like the 2014 Ebola epidemic, it is necessary to...
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CherryTemp heater/cooler for live-cell imaging

Dynamic & fast : 10 seconds temperature shifts


Stable & Precise : Long term stability


Discover the C. elegans heater/cooler
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