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HEART ON CHIP

Cherry_Biotech_heart_on_chip

Fibroblasts were grown and cultivated for 7 days

AIMS

→ Improve IPSc derived cardiomyocytes differentiation

→ Establish a Duchenne’s disease model on a chip

→ Combine electrical stimulations with biochemicals and bio-inductive extra cellular matrix

FEATURES

→ Temperature : 37°C

→ Gas : normoxia, 5% CO2

→ Perfusion mode : pulse

→ Culture unit : custom microfluidic chip

Cherry_Biotech_heart_on_chip

Cardiomyocytes derived from iPSCs were cultured for 4 days

Cherry_Biotech_heart_on_chip

Cardiomyocytes derived from iPSCs were cultured for 10 days. Contracting cardiomyocytes were obtained after 7 days of culture

RESULTS

→ Electrodes combination, biochemical and cell culture chamber in a tailored chip

→ Electrophysiological current detection to follow the differentiation stage

Myofilament immunofluorescence: sarcomere detection

Cherry_Biotech_CubiX

Cherry_Biotech_heart_on_chip

PERSPECTIVE

→ Standardize & Industrialize the protocol

→ Duchenne’s disease mechanism deciphering and drug testing

GET QUOTE

drapeau-europeThis project has received funding from H2020-MSCA-RISE2017 program under grant agreement No. 778354

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