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Liver function and liver on a chip

Liver is a fundamental organ for human life. It is responsible for macromolecules (carbohydrates, fats, protein) metabolization and the detoxification of our blood as well. Liver structure is complex and in vitro models based on 2D monoculture cannot recapitulate the liver physiological environment and functionality. A revolutionary approach comes from liver on a chip devices and 3D liver models which try to simulate human liver physiology by mimicking its microstructure and native conditions. These systems have a great potential for many applications (e.g., drug screening, innovative medicine). Moreover, they might be also exploited in combination with the last nanoscopy techniques to better understand liver nanostructures (e.g., fenestrations) which are involved is several hepatic diseases and processes.


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3d cell culture and organ on a chip device


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[5] Originally by Frevert U, Engelmann S, Zougbédé S, Stange J, Ng B, et al. Converted to SVG by Viacheslav Vtyurin who was hired to do so by User:Eug. [CC BY 2.5 https://creativecommons.org/licenses/by/2.5)], via Wikimedia Commons.

[6] Boumphreyfr [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], from Wikimedia Commons.https://upload.wikimedia.org/wikipedia/commons/4/4f/Hepatic_structure_He.svg

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