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Liver on a chip state of the art

Why a liver on a chip?

The liver is part of the digestive tract, and the main organ involved in the metabolism of xenobiotics, thus in toxicological studies (either fundamental or during the drug development path), it is mandatory to test the chemical on the liver. Currently in use models are badly predictive of what is then observed in human. Liver toxicity is one of the major causes of arrest during clinical phases of the development of a new drug, with the so-called Drug-Induced Liver Injury (DILI).

Fig 1: Liver anatomy - Liver on a chip [organ on a chip]

Fig 1: Liver anatomy


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1: Trends Biotechnol. 2017 Feb;35(2):172-183. doi: 10.1016/j.tibtech.2016.08.001. Epub 2016 Sep 2. Engineered Liver Platforms for Different Phases of Drug Development. Ware BR, Khetani SR

2: Exp Biol Med (Maywood). 2016 Jan; 241(1): 101–114. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Lawrence A Vernetti, Nina Senutovitch, Robert Boltz, Richard DeBiasio, Tong Ying Shun, Albert Gough, and D Lansing Taylor

3: http://www.biomemsrc.org/research/cell-tissue-microengineering/liver-on-a-chip

4: Biofabrication. 2016 Jan 12;8(1):014101. doi: 10.1088/1758-5090/8/1/014101. A liver-on-a-chip platform with bioprinted hepatic spheroids. Bhise NS1, Manoharan V, Massa S, Tamayol A, Ghaderi M, Miscuglio M, Lang Q, Shrike Zhang Y, Shin SR, Calzone G, Annabi N, Shupe TD, Bishop CE, Atala A, Dokmeci MR, Khademhosseini

And also :

Miniature liver on a chip could boost US food safety

Meet Chip: Liver (from NIH)

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

Written by Pierre Gaudriault

Written by Pierre Gaudriault

Innovation Unit | Intrapreneur

Pierre is incubated in our Entrepreneurship school. LEARN MORE.


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