AIMS
→ Characterization and quantification of antimigration and antiproliferative effects of several molecules, mimicking acute exposure.
→ Detection of specific biomarkers
FEATURES
→ Temperature : 37°C
→ Gas : normoxia 5% CO2
→ Perfusion mode : pulse & continuous
→ Culture unit : custom microfluidic chip
RESULTS
→ Spheroids viable during a 5 days experiment with perfusion of media
→ EC-50 of each molecule has been determined
→ Live detection and following of the biomarkers inside the chip
PERSPECTIVE
→ Mimicking chronic exposure
→ Multiplexing of chips to identify drug effect on other organs
Project financed by the Brittany region through the call for technology transfer projects
