Blood brain barrier microfluidic models [Brain on Chip]

Brain on a chip proof of concepts: what for?

Organs-on-chips are promising biological on chip laboratories expected to allow robust and accurate drug testing. Whether these micro-devices will be an alternative solution to animal drug testing, a revolutionary approach for personalized medicine or a complementary resource in the drug development industry remains to be addressed. Nevertheless, several laboratory proof-of-concept have been successfully performed, demonstrating the relevance of this approach. In this mini-review, we focused on devices mimicking the blood-brain barrier. These “Brain on chips” combine both the in vivo and in vitro advantages given that mimicking the reality and developing a simple ex vivo model is well balanced.

Fig. 1: Brain-on-a-chip and blood-brain barrier microfluidic devices as better ex vivo models. Fig. 1: Brain-on-a-chip and blood-brain barrier microfluidic devices as better ex vivo models.

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Bibliography/Sources

[1] Van der Helm MW, van der Meer AD, Eijkel JCT, van den Berg A, Segerink LI. Microfluidic organ-on-chip technology for blood-brain barrier research. Tissue Barriers. 2016; 4(1):e1142493. doi:10.1080/21688370.2016.1142493.

[2] Booth R, Kim H. Characterization of a microfluidic in vitro model of the blood-brain barrier (mu BBB). Lab Chip 2012; 12:1784-92; PMID:22422217; http://pubs.rsc.org/en/Content/ArticleLanding/2012/LC/c2lc40094d#!divAbstract

[3] Yeon JH, Na D, Choi K, Ryu SW, Choi C, Park JK. Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures. Biomedical Microdevices; 2012; 14:1141-1148, figure 1b; PMID:22821236

[4] Griep LM, Wolbers F, de Wagenaar B, ter Braak PM, Weksler BB, Romero IA, Couraud PO, Vermes I, van der Meer AD, van den Berg A. BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood- brain barrier function. Biomedical Microdevices; 2013; 15:145-150, figure 1a and 1c; PMID:22955726

[5] Achyuta AKH, Conway AJ, Crouse RB, Bannister EC, Lee RN, Katnik CP, Behensky AA, Cuevas J, Sundaram SS. A modular approach to create a neurovascular unit-on-a-chip. Lab Chip 2013; 13:542-53; PMID:23108480; http://dx.doi.org/ 10.1039/C2LC41033H

[6] Prabhakarpandian B, Shen MC,Nich- ols JB,Mills IR, Sidoryk-Wegrzynowicz M, Aschner M, Pant K. SyM-BBB: a microfluidic blood brain barrier model. Lab Chip 2013; 13:1093-101; PMID:23344641; http://dx.doi.org/10.1039/c2lc41208j

[7] Cho H, Seo JH, Wong KH, Terasaki Y, Park J, Bong K, Arai K, Lo EH, Irimia D. Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of neurovascular pathology. Sci Rep 2015; 5:15222

[8] Kim JA, Kim HN, Im SK, Chung S, Kang JY, Choi N. Collagen-based brain microvasculature model in vitro using three- dimensional printed template. Biomicrofluidics 2015; 9:024115.

[9] Brown JA, Pensabene V, Markov DA, Allwardt V, Neely MD, Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, et al. Recreat- ing blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Biomicrofluidics 2015; 9:054124.

[10] Sellgren KL, Hawkins BT, Grego S. An optically transparent membrane sup- ports shear stress studies in a three-dimensional micro- fluidic neurovascular unit model. Biomicrofluidics 2015; 9:061102.

[11] Walter FR, Valkai S, Kincses A, Petnehazi A, Czeller T, Veszelka S, Ormos P, Deli MA, Der A. A versatile lab-on-a-chip tool for modeling biological barriers, 1209-1219.

[12] Lei Z, Jiu-Chao Y, Hana Y, Ning-Xin M, Grace L, Xiangyun AC, Yanming Wa, Li L, Li C, Peng J, Gang-Yi W; Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell 2015. DOI: http://dx.doi.org/10.1016/j.stem.2015.09.012

See also :

Blood-brain-barrier content from Nature

Blood-brain-barrier definition from Wikipedia

Written by Thomas Guérinier

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