Project DeLIVERy — EIC Pathfinder Open Project

DeLIVERy - EIC Patchfiner Open Project

Long-term Microphysiological Sample Imaging for Evaluation of Polypharmacy in Liver

DELIVERy is an EIC pathfinder project aimed to build a radically new technology for personalized health care, which provides, for the first time, the possibility to investigate polypharmacy on individual patients.  The technology is combining micro-physiological systems (MPS) and super-resolution microscopy to allow physicians, biomedical scientists, and researchers to determine the phenotype at the nanoscale of human liver models and biopsies.

Objectives

Our role

  1. Conception and development of a  multiparametric and  MPS platform allowing liver biopsies, 3D models and cells phenotype maintenance and integration with the imaging system.
  2. Support on the MPS models and drug testing protocols development to the biological and medical partners.

Expected Results

PERT-chart-1202x1536
Figure 1: Representation of the various work packages within the project
Figure 2: Example of the effect of a research compound on liver fenestrations (LSEC nanosctructures used as morphological biomarkers). SIM images of LSEC with cell membrane stain, 40x40μm. Credit: Karolina Szafranska, University of Tromso.

References

Managing team

Jeremy Cramer - Founder & CEO
Jeremy Cramer

Outreach and Cherry Biotech Global Strategy Fit Responsible

This project has been funded by The European Union, under the grant agreement n° 101046928.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.

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Our expertise combines Microfluidic, 3DCell culture, Microscopy, Omics and artificial intelligence.
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