Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases
Introduction MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal...
Read MoreMelanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going?
Introduction Melanoma is clearly a complex disease with a high degree of...
Read MoreMicrofluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
Introduction The researchers created a microfluidic organ-on-chip solution with integrated electrochemical microsensor...
Read MoreA versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation
Introduction Animal models and two-dimensional (2D) cell cultures frequently fail to replicate...
Read MoreProbing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems
Introduction Adipose Tissue is very versatile and essential for studies related to...
Read MoreA new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept
Introduction The state of the art for tissues-on-chips using skin cells had...
Read MorePumpless, modular, microphysiological systems enabling tunable perfusion for long-term cultivation of endothelialized lumens
Introduction The authors present a simple and modular Microphysiological system without the...
Read MoreFacilitating implementation of organs-on-chips by open platform technology
Introduction Many Organ-on-Chip platforms are still not robust for all cell types,...
Read MoreThree-tissue microphysiological system for studying inflammatory responses in gut-liver Axis
Introduction The gut-liver axis is the bidirectional interaction that exists between the...
Read MoreLow-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip
Introduction In vitro generation of perfusable 3D microvessels is an important goal...
Read MoreCo-culture With Human Breast Adipocytes Differentially Regulates Protein Abundance in Breast Cancer Cells
Introduction In postmenopausal women, fat mass and adipose-tissue mass (see Human Breast...
Read MoreOrgan-on-Chips for Studying Tissue Barriers: Standard Techniques and a Novel Method for Including Porous Membranes Within Microfluidic Devices
Introduction Organ-on-Chips for Studying Tissue Barriers – Disruption of cell-formed tissue barriers...
Read MoreIsolation, Integration, and Culture of Human Mature Adipocytes Leveraging Organ-on-Chip Technology
Introduction Obesity and obesity-related co-morbidities are on the rise globally, necessitating the...
Read MoreUpcoming Organ-on-a-chip Conferences
Find out about all the upcoming Organ-on-a-chip Conferences and how to get...
Read MoreA Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease
Introduction Microfluidic 3D Endothelium-on-a-Chip – The endothelium is a thin membrane that...
Read More3D Microphysiological System- Vascularized Tissue Constructs for Regenerative Medicine
3D Microphysiological System Vascularized Tissue – Human vascular microphysiological systems (MPS) represent...
Read MoreOrgan-on-a-Chip: A New Paradigm for Drug Development
Introduction Organ-on-a-Chip is a potential, multidisciplinary method for in-vitro modeling of disease,...
Read MoreA Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip Systems
Introduction The extracellular matrix (ECM) is the non-cellular component present within all...
Read MoreAdipocyte-Endothelium Crosstalk in Obesity
Introduction The supporting vasculature is critical to the development of Adipose Tissue...
Read MoreThe vascular niche in next generation microphysiological systems
Introduction As a novel technology for in vitro toxicity testing platforms in...
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The TPLATE complex mediates membrane bending during plant clathrin-mediated endocytosis
Introduction While plant CME is actin independent, the authors identify that the...
Read MoreCell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development
Early cell divisions of the AB lineage, but not of the P/EMS...
Read MoreOrgan-on-chip applications in drug discovery: an end-user perspective
Introduction Organ-on-a-chip is regarded as a key new technology for research and...
Read MoreAdvanced models of human skeletal muscle differentiation, development and disease: 3D cultures, organoids and beyond
Introduction The organization and function of living muscle tissues cannot be fully...
Read MoreKidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing
Introduction Kidney Organoid and Microphysiological Kidney Chip Models, both have their own...
Read MoreBeyond Polydimethylsiloxane (PDMS): Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems
Introduction PDMS, often known as dimethylpolysiloxane or dimethicone, is a silicone polymer....
Read MorePharmacokinetics-On-a-Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME
Introduction Drug compounds’ effectiveness, toxicity, and pharmacokinetics may be more accurately predicted...
Read MoreLiver microphysiological platforms for drug metabolism applications
Introduction Liver microphysiological platforms for drug metabolism applications are the need of...
Read MoreAdipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction
Introduction Adipose tissue progenitor cells directly interact with endothelial cells to induce...
Read MoreA versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation
Introduction Recently, microfluidics and 3D cell culture technologies have merged, to increase...
Read MoreAdipocyte heterogeneity underlying adipose tissue functions
Introduction Adipose tissue does not only store energy, it also governs the...
Read MoreA new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept (Valencia et al, 2021)
Introduction Every organ is composed of a mesenchymal (stroma) and a parenchymal...
Read MoreRestorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice (Ishida et al, 2021)
Introduction Adipose tissue-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) that...
Read MorePerilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance (Gallardo-Montejano et al, 2021)
Introduction – According to a recent study headed by UT Southwestern researchers,...
Read MoreRebuilding the Vascular Network: In vivo and in vitro Approaches (Meng et al, 2021)
Introduction The vascular network carries the transportation of materials and nutrients as...
Read MoreExperimental liver models: from cell culture techniques to microfluidic organs-on-chip (Polidoro et al, 2021)
Introduction – The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device...
Read MoreObservation Internship (Stage d’observation) at Cherry Biotech – Lukas Marcel
Last week we had the pleasure of receiving Lukas Marcel as an...
Read MoreReview on the Vascularization of Organoids and Organoids-on-a-Chip (Xingli and Zilu et al, 2021)
Introduction Organoids and organs-on-a-chip (vascularized 3d culture) have seen rapid growth in...
Read MoreBinding of the SARS-CoV-2 Spike Protein to the Asialoglycoprotein Receptor on Human Primary Hepatocytes and Immortalized Hepatocyte-Like Cells by Confocal Analysis (Collins DP et al, 2021)
Summary SARS-CoV-2 is the virus that caused the COVID-19 pandemic and its...
Read MoreVascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes (Shamsi, F., Piper, M., Ho, LL. et al, 2021)
Introduction Brown fat is a kind of body fat that is activated...
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