3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

We offer a diverse portfolio of biology models testing services to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.

biological model	biological features	readouts	applications
LIVER ORGANOIDS	VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM SMART SPHEROPLATE ® MEDIUM PERFUSION STRONG/ NO GRADIENT NORMIXIA HYPOXIA CIRCULATING MONOCYTES FULLY RECONSTRUCTED HUMAN EPIDERMIS IMMUNOCOMPETENT CIRCULATING MONOCYTES NATURAL KILLER T-CELL RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2) SPECIALIZED IMMUNE CELLS "KUPFFER" (RESIDENT MACROPHAGE CELL) ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)	MICROSCOPY CONFOCAL IMMUNO LABELLING LIVE/ DEAD ASSAY IMMUNOCYTO-CHEMISTRY RTQPCR OXYGEN CONSUMPTION LACTATE GLUCOSE PRODUCTION/ CONSUMPTION LIVE IMAGING (MASS VARIATION, CELL MIGRATION)	DILI (DRUG INDUCED LIVER INJURY) IMMUNO MEDIATED DILI
FULLY DIFFERENTIATED SKIN			BIOCOMPABILITY (ISO 10993) IRRITATION VS OECD SENSITIZATION VS OECD TG 442E
melanoma equivalent			DMPK (liver metabolization, tumor penetration) Pharmacology (target validation, efficacy study) toxicology (bystander effect)
tumoroids
breast
custom model

biological model
LIVER ORGANOIDS
FULLY DIFFERENTIATED SKIN
melanoma equivalent
tumoroids
breast
custom model

biological features

VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
SMART SPHEROPLATE ®
MEDIUM PERFUSION
STRONG/ NO GRADIENT NORMIXIA HYPOXIA
CIRCULATING MONOCYTES
FULLY RECONSTRUCTED HUMAN EPIDERMIS
IMMUNOCOMPETENT
CIRCULATING MONOCYTES
NATURAL KILLER T-CELL
RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
SPECIALIZED IMMUNE CELLS "KUPFFER" (RESIDENT DENDRITIC CELL)
ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)

Readouts

MICROSCOPY CONFOCAL
IMMUNO LABELLING
LIVE/ DEAD ASSAY
IMMUNOCYTO-CHEMISTRY
RTQPCR
OXYGEN CONSUMPTION
LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
LIVE IMAGING (MASS VARIATION, CELL MIGRATION)

Applications

DILI (DRUG INDUCED LIVER INJURY)
IMMUNO MEDIATED DILI

BIOCOMPABILITY (ISO 10993)
IRRITATION VS OECD
SENSITIZATION VS OECD TG 442E

DMPK (liver metabolization, tumor penetration)
Pharmacology (target validation, efficacy study)
toxicology (bystander effect)

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss with our experts to determine the best models for your project (either yours, or pick from our models catalog)
Select the Model
Determine the set of readouts, types of cells and experimental plan
We perform the study using our Microphysiological system CubiX to accurately mimic a vascularized human organ in vitro
Receive a full report with the option to obtain cell and medium samples