3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

Our 3D CRO service offers a diverse portfolio of biology models to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.

biological model biological features readouts applications

LIVER ORGANOIDS

  • VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
  • SMART SPHEROPLATE ®
  • MEDIUM PERFUSION
  • STRONG/ NO GRADIENT NORMIXIA HYPOXIA
  • CIRCULATING MONOCYTES
  • FULLY RECONSTRUCTED HUMAN EPIDERMIS
  • IMMUNOCOMPETENT
  • CIRCULATING MONOCYTES
  • NATURAL KILLER T-CELL
  • RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
  • SPECIALIZED IMMUNE CELLS “KUPFFER” (RESIDENT MACROPHAGE CELL)
  • ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
  • ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
  • EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)
  • MICROSCOPY CONFOCAL
  • IMMUNO LABELLING
  • LIVE/ DEAD ASSAY
  • IMMUNOCYTO-CHEMISTRY
  • RTQPCR
  • OXYGEN CONSUMPTION
  • LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
  • LIVE IMAGING (MASS VARIATION, CELL MIGRATION)
  • DILI (DRUG INDUCED LIVER INJURY)
  • IMMUNO MEDIATED DILI

FULLY DIFFERENTIATED SKIN

  • BIOCOMPABILITY (ISO 10993)
  • IRRITATION VS OECD
  • SENSITIZATION VS OECD TG 442E

melanoma equivalent

  • DMPK (liver metabolization, tumor penetration)
  • Pharmacology (target validation, efficacy study)
  • toxicology (bystander effect)

tumoroids

breast

custom model

biological model

LIVER ORGANOIDS

FULLY DIFFERENTIATED SKIN

melanoma equivalent

tumoroids

breast

custom model

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss your project vision with our expert

Select the Model

Select the set of Readouts, Types of cells & Experiment plan

Experiment

We perform the study using our Microphysiological system (MPS) CubiX to accurately mimic a vascularized human organ in 3D in vitro

Deliverable

related resources

Figure1-3D-liver-cell-culture-liver-on-a-chip-structure-liver
The Complexity Behind the 3D Cell Cultures: the 3D Liver Cell Cul...
Introduction Once it is clear how to deal with 3D cell cultures it is time to focus on one type of cell and analyze its strengths and its li...
Read more
Liver Biopsies Beyond Histological Diagnosis: Ex-vivo Culturing a...
The Liver: Overview, Histology and Pathology The liver (Fig. 1) is the largest organ in the human body and responsible for 1stand 2nd pass ...
Read more
Word cloud illustration centered on the "3Rs" (Replacement, Reduction, Refinement), surrounded by key terms in alternative testing such as FDA Modernization Act 2.0, Organ-on-Chip, NAMs, ECVAM, and Bioethics.
The evolution of alternatives to animal testing: A 3R timeline...
For over a century, animal experimentation has served as the bedrock of biomedical research and toxicology. From elucidating basic physiolog...
Read more

They trust Us

custom your service

For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service
As part of our commercial prospecting, we may need to process your personal data. For more information, please consult our Privacy Policy