3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

We offer a diverse portfolio of biology models testing services to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.
biological model biological features readouts applications

LIVER ORGANOIDS

  • VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
  • SMART SPHEROPLATE ®
  • MEDIUM PERFUSION
  • STRONG/ NO GRADIENT NORMIXIA HYPOXIA
  • CIRCULATING MONOCYTES
  • FULLY RECONSTRUCTED HUMAN EPIDERMIS
  • IMMUNOCOMPETENT
  • CIRCULATING MONOCYTES
  • NATURAL KILLER T-CELL
  • RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
  • SPECIALIZED IMMUNE CELLS "KUPFFER" (RESIDENT DENDRITIC CELL)
  • ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
  • ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
  • EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)
  • MICROSCOPY CONFOCAL
  • IMMUNO LABELLING
  • LIVE/ DEAD ASSAY
  • IMMUNOCYTO-CHEMISTRY
  • RTQPCR
  • OXYGEN CONSUMPTION
  • LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
  • LIVE IMAGING (MASS VARIATION, CELL MIGRATION)
  • DILI (DRUG INDUCED LIVER INJURY)
  • IMMUNO MEDIATED DILI

FULLY DIFFERENTIATED SKIN

  • BIOCOMPABILITY (ISO 10993)
  • IRRITATION VS OECD
  • SENSITIZATION VS OECD TG 442E

melanoma equivalent

  • DMPK (liver metabolization, tumor penetration)
  • Pharmacology (target validation, efficacy study)
  • toxicology (bystander effect)

tumoroids

breast

custom model

biological model

LIVER ORGANOIDS

FULLY DIFFERENTIATED SKIN

melanoma equivalent

tumoroids

breast

custom model

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss your project vision with our expert

Select the Model

Select the set of Readouts, Types of cells & Experiment plan

Experiment

We perform the study using our Microphysiological system (MPS) CubiX to accurately mimic a vascularized human organ in 3D virto

Deliverable

related resources

Tumor_targeting
3D cell culture and anticancer drug testing...
Efficacity and toxicity of candidate anticancer drugs has been assessed on 2D cell culture models over the past few decades. This model has ...
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Scientific Poster – Skin sensitization and safety assessment ba...
SCIENTIFIC POSTER DOWLOAD — Skin sensitization and safety assessment based on an in vitro 3D vascularized fully differentiated immunocompe...
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Scientific Poster – in vitro human vascularized immunocompetent...
SCIENTIFIC POSTER DOWLOAD — Towards the development of an in vitro human vascularized immunocompetent metastatic melanoma-on-chip model El...
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They trust Us

custom your service

For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service