3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

Our 3D CRO service offers a diverse portfolio of biology models to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.

biological model biological features readouts applications

LIVER ORGANOIDS

  • VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
  • SMART SPHEROPLATE ®
  • MEDIUM PERFUSION
  • STRONG/ NO GRADIENT NORMIXIA HYPOXIA
  • CIRCULATING MONOCYTES
  • FULLY RECONSTRUCTED HUMAN EPIDERMIS
  • IMMUNOCOMPETENT
  • CIRCULATING MONOCYTES
  • NATURAL KILLER T-CELL
  • RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
  • SPECIALIZED IMMUNE CELLS “KUPFFER” (RESIDENT MACROPHAGE CELL)
  • ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
  • ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
  • EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)
  • MICROSCOPY CONFOCAL
  • IMMUNO LABELLING
  • LIVE/ DEAD ASSAY
  • IMMUNOCYTO-CHEMISTRY
  • RTQPCR
  • OXYGEN CONSUMPTION
  • LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
  • LIVE IMAGING (MASS VARIATION, CELL MIGRATION)
  • DILI (DRUG INDUCED LIVER INJURY)
  • IMMUNO MEDIATED DILI

FULLY DIFFERENTIATED SKIN

  • BIOCOMPABILITY (ISO 10993)
  • IRRITATION VS OECD
  • SENSITIZATION VS OECD TG 442E

melanoma equivalent

  • DMPK (liver metabolization, tumor penetration)
  • Pharmacology (target validation, efficacy study)
  • toxicology (bystander effect)

tumoroids

breast

custom model

biological model

LIVER ORGANOIDS

FULLY DIFFERENTIATED SKIN

melanoma equivalent

tumoroids

breast

custom model

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss your project vision with our expert

Select the Model

Select the set of Readouts, Types of cells & Experiment plan

Experiment

We perform the study using our Microphysiological system (MPS) CubiX to accurately mimic a vascularized human organ in 3D in vitro

Deliverable

related resources

Circular systems diagram linking six nodes—Fibrosis, Metabolism, Inflammation, Thermogenesis, Hypoxia, and Adipogenesis—by colored arrows that illustrate how each process amplifies the others; side notes list typical increases (e.g., ECM collagen, pro-inflammatory cytokines, hypertrophy) and decreases (e.g., adiponectin, angiogenesis, beiging of white fat).
Understanding Adipose Tissue: A Key to Drug Discovery in Metaboli...
What Does Adipose Tissue Do? Adipose tissue is more than a fat storage site, it’s a dynamic endocrine organ central to metabolic health. I...
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Table comparing 3D liver cell models and their best uses. Rows: HepG2 spheroids: high scalability/HTS-ready, greater structural resistance, shift to quiescent tissue-like state; optimal for early HTS (acute cytotoxicity). HepaRG spheroids: high, stable CYP activity with robust induction; metabolically superior to HepG2; optimal for early–mid HTS (metabolism/DDI screening). PHH spheroids: gold-standard metabolic fidelity and weeks-long functional longevity; best correlation with in vivo CYP induction; optimal for late preclinical de-risking (chronic DILI, MoA).
From 2D to 3D: Restoring in vitro liver models functions...
In our previous article, we outlined the main in vitro liver models, immortalized cell lines such as HepG2 and HepaRG, alongside primary hep...
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Flowchart showing the steps used to create patient-derived tumor organoids (PDTOs): starting at left with a human silhouette and icons for “biological fluids” and “tumor”, followed by enzymatic/mechanical dissociation equipment; a tube containing isolated cells; embedding of cells in an extracellular-matrix dome inside a culture well; addition of enriched medium; formation of PDTOs; parallel branches for characterization (histology slide, sequencing machine), research assays (multi-well plate, radiation symbol, pill), and cryopreservation (vial rack); arrows trace feedback from PDTO characterization back to the original tumor to correlate findings.
Breast cancer organoid: A short history of innovation in breast c...
Breast cancer has long been one of the most prevalent and challenging cancers worldwide, demanding constant advances in treatment and resear...
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custom your service

For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service
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