3D In vitro contract research service

Why
3D in vitro ?

With the change in regulations that no longer require animal testing models as compulsory, there is a growing anticipation of 2D/3D models as an alternative for drug testing.

Our contract research service offers a great solution that respects animal welfare and experiment ethics while providing a competitive advantage for clients in drug development.

By utilizing our CRO 3D in-vitro activity testing and CubiX microphysiological system, clients can achieve greater accuracy and precision without the need for animal testing. With a focus on moral values and innovation, our service offers a more ethical and efficient approach to drug development.

service highlights

Our CRO service provides standard and custom in vitro studies using organ-on-a-well (OOW) technology to support drug development.

Our service highlights:

Human-relevant 3D in vitro models

Our Microphisiology technology generates human-relevant data that is more predictive of clinical outcomes compared to animal studies.

Access to OOW technology without investing in equipment

Save time and resources by outsourcing your in vitro studies to our team of experts who have the necessary equipment and expertise to conduct experiments.

Time saving & cost-effective results

Our contract research service team works with you to design and execute studies that yield results quickly and cost-effectively compared to traditional animal studies.

Cutting-edge expertise in Organ-on-Well technology

Our patented Organ-On-Well technology allows full- compatibility with the industry standard. Combine with the meticulous knowledge of our team of scientists, we can provide your team valuable insights and recommendations to improve your drug development programs.

Proven track record for delivering clinically translatable results

We have a history of providing results that are translatable to clinical outcomes, which can help you progress your drug candidates towards successful clinical trials.

related resources

Flowchart showing the steps used to create patient-derived tumor organoids (PDTOs): starting at left with a human silhouette and icons for “biological fluids” and “tumor”, followed by enzymatic/mechanical dissociation equipment; a tube containing isolated cells; embedding of cells in an extracellular-matrix dome inside a culture well; addition of enriched medium; formation of PDTOs; parallel branches for characterization (histology slide, sequencing machine), research assays (multi-well plate, radiation symbol, pill), and cryopreservation (vial rack); arrows trace feedback from PDTO characterization back to the original tumor to correlate findings.

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$Schematic representation of an adipose-tissue-on-chip module illustrating the principal engineering elements that enhance physiological relevance: (i) perfusable lumen with circulating immune cells permitting real-time trafficking; (ii) endothelial monolayer aligned by shear stress to maintain a selective barrier; (iii) continuous perfusion for nutrient delivery and waste removal; (iv) controlled gas exchange enabling oxygen tuning and hypoxia modelling; (v) intrinsic, perfused microvasculature embedded within the stromal-vascular fraction; and (vi) fluidic coupling to a downstream liver compartment to study multi-organ crosstalk. A legend identifies the main cell types and extracellular matrix components.$

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They trust Us

"We appreciated having the CubiX in the lab to perform experiments, where we could take advantage of a 6-well flow system. The flow system allows control of the percentages of N2, CO2, and O2 to enrich the media of the biological samples without needing an incubator. In this system we were able to use disposable transwells, which saved costs for the development of our skin/melanoma -on-chip models, and allowed us to use pre-established protocols, with little adjustments."

"The flexibility and potential for customization of the CubiX system is of great benefit for our experiments and ongoing work"

"By offering a simple-to-use device, compatible with long-term in-line data recording and adjustable microenvironment, the CubiX system and the CherryBiotech team provide a highly valuable tool to design realistic pre-clinical models for therapeutical purposes, in pair with an advanced platform for research purposes. We have been enjoying our collaboration and certainly look forward for more projects and a stronger integration in the Gustave Roussy comprehensive cancer center."

Our experience with the Cubix® prototype provided by Cherry Biotech has been positive. The support team was exceptionally responsive and helpful, making the process smooth and efficient. While the overall functionality of the bioreactor is impressive, we did encounter some challenges with troubleshooting minor issues and assembling the tubings. Additionally, the software could benefit from some UI improvements to enhance usability. Despite these minor points , the advantages of the Cubix® system are invaluable to our lab in advancing our research on liver biology, and we are eager to continue our collaboration with Cherry Biotech in the future

custom your service

For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service

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Replacing animal testing through technological convergence