Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases
Introduction MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal experimentation and improve preclinical
Organs-on-a-chip
Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going?
Introduction Melanoma is clearly a complex disease with a high degree of heterogeneity and adaptability. Melanoma
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
Introduction The researchers created a microfluidic organ-on-chip solution with integrated electrochemical microsensor arrays enabling compartmentalized matrix-based
A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation
Introduction Animal models and two-dimensional (2D) cell cultures frequently fail to replicate human drug metabolism and
Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems
Introduction Adipose Tissue is very versatile and essential for studies related to Obesity and Diabetes, however,
Pumpless, modular, microphysiological systems enabling tunable perfusion for long-term cultivation of endothelialized lumens
Introduction The authors present a simple and modular Microphysiological system without the use of complex components
Facilitating implementation of organs-on-chips by open platform technology
Introduction Many Organ-on-Chip platforms are still not robust for all cell types, are not reproducible from
Three-tissue microphysiological system for studying inflammatory responses in gut-liver Axis
Introduction The gut-liver axis is the bidirectional interaction that exists between the gut and its microbiota,
Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip
Introduction In vitro generation of perfusable 3D microvessels is an important goal for tissue engineering and
Co-culture With Human Breast Adipocytes Differentially Regulates Protein Abundance in Breast Cancer Cells
Introduction In postmenopausal women, fat mass and adipose-tissue mass (see Human Breast Adipocytes) are closely linked
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