Pancreas on a chip : State of the Art

Why a pancreas on a chip?

The pancreas is an annex gland of the digestive system. It has both endocrine and exocrine functionality. Its exocrine function consists of the secretion of digestive fluids containing enzyme facilitating the digestion of fatty acids. Its endocrine function is based on hormone secretion that regulates glycemia (insulin, glucagon). Pancreas cancer is generally associated with bad prognostic, thus there a real need for new therapies.

Fig 1: Pancreas Anatomy - Pancreas on a chip [organ on a chip] Fig 1: Pancreas Anatomy


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1: Anal Chem. 2009 Apr 15; 81(8): 3119–3127. doi:  10.1021/ac900109t. Quantitative Monitoring of Insulin Secretion from Single Islets of Langerhans in Parallel on a Microfluidic Chip. John F. Dishinger Kendra R. Reid, and Robert T. Kennedy

2: Anal Chem. 2013 Dec 3;85(23):11240-9. doi: 10.1021/ac401297v. Epub 2013 Nov 15. Microfluidic array with integrated oxygenation control for real-time live-cell imaging: effect of hypoxia on physiology of microencapsulated pancreatic islets. Nourmohammadzadeh M1, Lo JF, Bochenek M, Mendoza-Elias JE, Wang Q, Li Z, Zeng L, Qi M, Eddington DT, Oberholzer J, Wang Y.

3: Neuro Endocrinol Lett. 2009;30(2):204-8. Dynamic analysis of bone marrow mesenchymal stem cells migrating to pancreatic islets using coculture microfluidic chips: An accelerated migrating rate and better survival of pancreatic islets were revealed. Lin P1, Chen L, Li D, Yang N, Sun Y, Xu Y

4: Biomaterials. 2014 Jun;35(17):4815-26. doi: 10.1016/j.biomaterials.2014.02.045. Epub 2014 Mar 15. Microchip-based engineering of super-pancreatic islets supported by adipose-derived stem cells. Jun Y, Kang AR, Lee JS, Park SJ, Lee DY, Moon SH, Lee SH

5: Biofabrication. 2017 Feb 21;9(1):015021. doi: 10.1088/1758-5090/aa5cc9. Endocrine system on chip for a diabetes treatment model. Nguyen DT1, van Noort D, Jeong IK, Park S.

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