Scientific notes

Exploratory Analysis Of Transposable Elements Expression In The C. elegans Early Embryo

Introduction

Transposable Elements are expressed in the C. elegans early embryo and involved in his development, but they might also have an impact on pathologies and neurodegenerative diseases.

Transposable Elements (TE) are mobile sequences present throughout the genome. Their involvement in physiological and pathological processes needs to be clarified but appears to be related. This work of Federico Ansaloni et al. is about the expression and regulation of TE during different stages of embryogenesis.

They highlight TE transcription regulation in this model, even if its low, different TE are expressed in different cell types and stages, suggesting functions during early embryo development.

Ultra fast temperature shift device for in vitro experiments under microscopy

Abstract

“Transposable Elements (TE) are mobile sequences that make up large portions of eukaryote genomes. The functions they play within the complex cellular architecture are still not clearly understood, but it is becoming evident that TE have a role in several physiological and pathological processes. In particular, it has been shown that TE transcription is necessary for the correct development of mice embryos and that their expression is able to finely modulate transcription of coding and non-coding genes. Moreover, their activity in the central nervous system (CNS) and other tissues has been correlated with the creation of somatic mosaicisms and with pathologies such as neurodevelopmental and neurodegenerative diseases as well as cancers.”

References

Related Posts

Requirement For Translocon-associated Protein (TRAP) Α In Insuli...
Engineered C. elegans as a model organism for a better understanding of type 2 diabetes in humans To better understand the mechanisms of pep...
Read more
Cell Lineage-dependent Chiral Actomyosin Flows Drive Cellular Rea...
The importance of chiral rotatory movements of the actomyosin cortex, involve in cellular rearrangements, during C. elegans embryo developme...
Read more
The Daf-2 Insulin Receptor Functions In C. elegans Embryo Elongat...
Role of Daf-2 insulin signaling in the embryonic elongation of C. elegans, a daf-2 loss of function seems to vary according to the allele in...
Read more

get in touch

Get the best insights about Cherry Biotech by Email Let’s stay in touch!
Scroll to Top