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Tumor microenvironment (TME)

The tumor microenvironment (TME) is a complex biochemical network which includes multiple factors surrounding tumor cells, such as vascular networks, the extracellular matrix (ECM), and an heterogenous cell population composed by multiple cell types like fibroblast or immune cells.

This Scientific Note briefly describes the main components of the TME and their interactions, together with their role in tumor growth and tumor evolution.

Cancer cells are surrounded by a complex tumor microenvironment

Cancer cells are surrounded by a complex tumor microenvironment


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[1] Chen C.S. 3D Biomimetic Cultures: The Next Platform for Cell Biology. Trends in Cell Biology (2016).  https://www.ncbi.nlm.nih.gov/pubmed/27637342

[2] Castells M. et al. Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death. Int. J. Mol. Sci. 2012 https://www.ncbi.nlm.nih.gov/pubmed/22949815

[3] Jo Y. et al.  Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development. Theranostics. 2018. https://www.ncbi.nlm.nih.gov/pubmed/30555545

[4] Li HC et al. Tumor microenvironment: The role of the tumor stroma in cancer. J Cell Biochem. 2007  https://www.ncbi.nlm.nih.gov/pubmed/17226777

[5] Finger EC. and Giaccia AJ. Cancer Metastasis Rev. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease (2010) https://www.ncbi.nlm.nih.gov/pubmed/20393783

[6] Hanahan D. and Coussens LM. Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment”. Cancer Cell (2012) https://www.ncbi.nlm.nih.gov/pubmed/22439926





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