Authors: Mathilde Cadoux, PhD; Emilie Ouanounou; Ghofrane Ben Messaoud; Hadhemi Mejri; Julius Elliot Nyegaard Grothen, PhD; Thomas Askov Pedersen, PhD; Dario Fassini, PhD
Metabolic diseases are strongly linked to adipose tissue dysfunction, yet current in vitro models poorly capture the biology of mature white adipose tissue.
In collaboration with Novo Nordisk, we optimized protocols to generate SVF-derived adipose organoids using Cherry Biotech’s CubiX microphysiological system. Our work focused on:
- Developing SVF-derived
organoids reproducing key features of white adipose tissue, including
unilocular adipocytes and endothelial cells - Exploring perfusion and
hydrogel effects on adipose organoid morphology, viability, and
differentiation - Validating cryopreserved SVF as
a robust source, enabling reproducible and physiologically relevant white adipose tissue models
Download our poster to discover how this model supports metabolic disease research and drug discovery.
In this study, CubiX has enabled precise control of oxygen, nutrients, and flow, supporting the advancement of more refined and reliable in vitro organoid models.
The poster, titled: Charting new paths in adipose tissue organoid development via stromal vascular fraction – is free to download here. Don’t miss out!
