Abstract of mmb1p Binds Mitochondria to Dynamic Microtubules
Mitochondria form a dynamic tubular network within the cell. Proper mitochondria movement and distribution are critical for their localized function in cell metabolism, growth, and survival. In mammalian cells, mechanisms of mitochondria positioning appear dependent on the microtubule cytoskeleton, with kinesin or dynein motors carrying mitochondria as cargos and distributing them throughout the microtubule network. Interestingly, the timescale of microtubule dynamics occurs in seconds, and the timescale of mitochondria distribution occurs in minutes. How does the cell couple these two time constants?
Video extracted from the publication.
How to culture vascularized & immunocompetent 3D models in a standard Multiwell
References
https://www.sciencedirect.com/science/article/pii/S0960982211007822Chuanhai Fu, Deeptee Jain, Judite Costa, Guilhem Velve-Casquillas, Phong T. Tran, mmb1p Binds Mitochondria to Dynamic Microtubules, Current Biology, Volume 21, Issue 17, 2011, Pages 1431-1439,
