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A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution
A fundamental breakthrough in the understanding of development through the realization of the complete transcriptome of C. elegans, from the embryo to the terminal ...
Read moreThe size a ruling element in embryo to determine the fate and the function, suggesting cells are sensing size and can make decisions based on it
During early embryonic development polarity and asymmetric division are essential elements. In this paper Lars Hubatch et al. showed the significance of cell size in stem ...
Read moreHEART ON CHIP
Fibroblasts were grown and cultivated for 7 days AIMS → Improve IPSc derived cardiomyocytes differentiation → Establish a Duchenne's disease model on a chip → Combine electrical stimulations with biochemicals ...
Read moreFULLY DIFFERENTIATED SKIN ON CHIP
Reijnders CMA,...Gibbs S, Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts, Tissue Eng Part A. 2015 Sep 1; ...
Read moreLIVER BIOPSY ON CHIP
AIMS → Increase biopsies viability in long term culture → Imaging and biochemical quantification of drug effect → Interface blood vessel/hepatocyte → DILI assessment based on biochemical marker and morphometric read-out FEATURES → ...
Read moreSPHEROID HUMAN KIDNEY CANCER ON CHIP
AIMS → Characterization and quantification of antimigration and antiproliferative effects of several molecules, mimicking acute exposure. → Detection of specific biomarkers FEATURES → Temperature : 37°C → Gas : normoxia 5% CO2 → Perfusion ...
Read moreHUMAN BIOPSIES CULTURE
AIMS → Tumor(s) cells sequential exposure to compounds in different wells (drugs, antibodies, reagents) → Maintain automatic perfusion at a constant flow rate → Live optical readouts acquisition (fluorescence) FEATURES → Temperature ...
Read moreLONG TERM KIDNEY TISSUE CULTURE
AIMS → Human kidney culture for 7 days → Automatic perfusion at a flow rate → Live optical readouts acquisition (fluorescence) FEATURES → Temperature : 37°C → Gas : normoxia, 5% CO2 → Perfusion mode : pulse → Culture ...
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