3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

Our 3D CRO service offers a diverse portfolio of biology models to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.

biological model biological features readouts applications

LIVER ORGANOIDS

  • VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
  • SMART SPHEROPLATE ®
  • MEDIUM PERFUSION
  • STRONG/ NO GRADIENT NORMIXIA HYPOXIA
  • CIRCULATING MONOCYTES
  • FULLY RECONSTRUCTED HUMAN EPIDERMIS
  • IMMUNOCOMPETENT
  • CIRCULATING MONOCYTES
  • NATURAL KILLER T-CELL
  • RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
  • SPECIALIZED IMMUNE CELLS “KUPFFER” (RESIDENT MACROPHAGE CELL)
  • ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
  • ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
  • EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)
  • MICROSCOPY CONFOCAL
  • IMMUNO LABELLING
  • LIVE/ DEAD ASSAY
  • IMMUNOCYTO-CHEMISTRY
  • RTQPCR
  • OXYGEN CONSUMPTION
  • LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
  • LIVE IMAGING (MASS VARIATION, CELL MIGRATION)
  • DILI (DRUG INDUCED LIVER INJURY)
  • IMMUNO MEDIATED DILI

FULLY DIFFERENTIATED SKIN

  • BIOCOMPABILITY (ISO 10993)
  • IRRITATION VS OECD
  • SENSITIZATION VS OECD TG 442E

melanoma equivalent

  • DMPK (liver metabolization, tumor penetration)
  • Pharmacology (target validation, efficacy study)
  • toxicology (bystander effect)

tumoroids

breast

custom model

biological model

LIVER ORGANOIDS

FULLY DIFFERENTIATED SKIN

melanoma equivalent

tumoroids

breast

custom model

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss your project vision with our expert

Select the Model

Select the set of Readouts, Types of cells & Experiment plan

Experiment

We perform the study using our Microphysiological system (MPS) CubiX to accurately mimic a vascularized human organ in 3D in vitro

Deliverable

related resources

High-resolution photo of a microfluidic organ-on-chip under a microscope, USB-linked to a laptop that displays breast-cancer imaging and analytics graphs.
Organoid and artificial intelligence in breast cancer research...
Introduction Organoid and artificial intelligence approaches are central to the FDA’s roadmap for reducing animal use in preclinical safet...
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A side-by-side comparison. On the left, an 'SVF-Derived Organoid' is a complex sphere of pre-adipocytes, endothelial networks, and immune cells. On the right, an 'ADSC-Based Spheroid' is a uniform sphere of only pre-adipocytes.
SVF vs ADSC for 3D adipose culture: What source to use?...
In this discussion, we investigate the optimal cell source for constructing 3D adipose models, predicated on the specific research objective...
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3D-cell-culture-human-on-a-chip-cubix-cherrybiotech
Pharmacokinetics-On-a-Chip: In Vitro Microphysiological Models fo...
Introduction Microphysiological systems may predict drug pharmacokinetics, effectiveness and toxicity more accurately in humans. Pharmacoki...
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custom your service

For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service
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