3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

Our 3D CRO service offers a diverse portfolio of biology models to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.

biological model biological features readouts applications

LIVER ORGANOIDS

  • VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
  • SMART SPHEROPLATE ®
  • MEDIUM PERFUSION
  • STRONG/ NO GRADIENT NORMIXIA HYPOXIA
  • CIRCULATING MONOCYTES
  • FULLY RECONSTRUCTED HUMAN EPIDERMIS
  • IMMUNOCOMPETENT
  • CIRCULATING MONOCYTES
  • NATURAL KILLER T-CELL
  • RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
  • SPECIALIZED IMMUNE CELLS “KUPFFER” (RESIDENT MACROPHAGE CELL)
  • ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
  • ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
  • EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)
  • MICROSCOPY CONFOCAL
  • IMMUNO LABELLING
  • LIVE/ DEAD ASSAY
  • IMMUNOCYTO-CHEMISTRY
  • RTQPCR
  • OXYGEN CONSUMPTION
  • LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
  • LIVE IMAGING (MASS VARIATION, CELL MIGRATION)
  • DILI (DRUG INDUCED LIVER INJURY)
  • IMMUNO MEDIATED DILI

FULLY DIFFERENTIATED SKIN

  • BIOCOMPABILITY (ISO 10993)
  • IRRITATION VS OECD
  • SENSITIZATION VS OECD TG 442E

melanoma equivalent

  • DMPK (liver metabolization, tumor penetration)
  • Pharmacology (target validation, efficacy study)
  • toxicology (bystander effect)

tumoroids

breast

custom model

biological model

LIVER ORGANOIDS

FULLY DIFFERENTIATED SKIN

melanoma equivalent

tumoroids

breast

custom model

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss your project vision with our expert

Select the Model

Select the set of Readouts, Types of cells & Experiment plan

Experiment

We perform the study using our Microphysiological system (MPS) CubiX to accurately mimic a vascularized human organ in 3D in vitro

Deliverable

related resources

Circular systems diagram linking six nodes—Fibrosis, Metabolism, Inflammation, Thermogenesis, Hypoxia, and Adipogenesis—by colored arrows that illustrate how each process amplifies the others; side notes list typical increases (e.g., ECM collagen, pro-inflammatory cytokines, hypertrophy) and decreases (e.g., adiponectin, angiogenesis, beiging of white fat).
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Schematic of adipose tissue–breast cancer crosstalk: obese adipose tissue secretes adipokines and lipids, drives cancer cell growth and therapy resistance, and forms CAAs.
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custom your service

For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service
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