3D In vitro contract research services

Which service do we provide ?

Discover our main Applications

Our 3D CRO service offers a diverse portfolio of biology models to improve the likelihood of success in your clinical trials. Below is a list of our standard application offerings.

biological model biological features readouts applications

LIVER ORGANOIDS

  • VASCULARIZATION DIFFERENTIATED FUNCTIONAL ENDOTHELIUM
  • SMART SPHEROPLATE ®
  • MEDIUM PERFUSION
  • STRONG/ NO GRADIENT NORMIXIA HYPOXIA
  • CIRCULATING MONOCYTES
  • FULLY RECONSTRUCTED HUMAN EPIDERMIS
  • IMMUNOCOMPETENT
  • CIRCULATING MONOCYTES
  • NATURAL KILLER T-CELL
  • RESIDENT IMMUNITY MACROPHAGE (M0 M1, M2)
  • SPECIALIZED IMMUNE CELLS “KUPFFER” (RESIDENT MACROPHAGE CELL)
  • ALTERATED/ NORMAL ENDOTHELIUM PERMABILITY
  • ASSOCIATED CELLS (FIBROBLAST, ADIPOCYTE
  • EXTRA CELLULAR MATRIX (ECM, COLLAGEN, MATRIGEL, COMMERCIAL MATRIX)
  • MICROSCOPY CONFOCAL
  • IMMUNO LABELLING
  • LIVE/ DEAD ASSAY
  • IMMUNOCYTO-CHEMISTRY
  • RTQPCR
  • OXYGEN CONSUMPTION
  • LACTATE GLUCOSE PRODUCTION/ CONSUMPTION
  • LIVE IMAGING (MASS VARIATION, CELL MIGRATION)
  • DILI (DRUG INDUCED LIVER INJURY)
  • IMMUNO MEDIATED DILI

FULLY DIFFERENTIATED SKIN

  • BIOCOMPABILITY (ISO 10993)
  • IRRITATION VS OECD
  • SENSITIZATION VS OECD TG 442E

melanoma equivalent

  • DMPK (liver metabolization, tumor penetration)
  • Pharmacology (target validation, efficacy study)
  • toxicology (bystander effect)

tumoroids

breast

custom model

biological model

LIVER ORGANOIDS

FULLY DIFFERENTIATED SKIN

melanoma equivalent

tumoroids

breast

custom model

How does it work?

Cherry Biotech’s CRO service is a step by step process designed to provide customers with accurate and reliable invitro data for drug development:

Discuss your project vision with our expert

Select the Model

Select the set of Readouts, Types of cells & Experiment plan

Experiment

We perform the study using our Microphysiological system (MPS) CubiX to accurately mimic a vascularized human organ in 3D in vitro

Deliverable

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For your preclinical tox-efficacy studies,
let our expertise in immune competent vascularized human organ models be at your service
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