Brown vs White Adipose Tissue: What is at Stake for Pharma
As the global obesity crisis intensifies, the functional contrast between brown adipose tissue and white adipose
Liver
Transforming Preclinical Testing with Adipose Tissue Organoids
Over the past decade, three-dimensional “organoid” cultures have evolved from proof-of-concept curiosities into influential tools for
Animal Testing Landscape 2025
About this white paper Animal testing has played a crucial role in medical advancements, leading to
A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation
Introduction Animal models and two-dimensional (2D) cell cultures frequently fail to replicate human drug metabolism and liver
Three-tissue microphysiological system for studying inflammatory responses in gut-liver Axis
Introduction The gut-liver axis is the bidirectional interaction that exists between the gut and its microbiota,
Liver microphysiological platforms for drug metabolism applications
Introduction Liver microphysiological platforms for drug metabolism applications are the need of the hour to fix the exorbitant
Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice (Ishida et al, 2021)
Introduction Adipose tissue-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) that are obtained from abundant
Experimental liver models: from cell culture techniques to microfluidic organs-on-chip (Polidoro et al, 2021)
Introduction The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device based on a microfluidic chip in the
Binding of the SARS-CoV-2 Spike Protein to the Asialoglycoprotein Receptor on Human Primary Hepatocytes and Immortalized Hepatocyte-Like Cells by Confocal Analysis (Collins DP et al, 2021)
Introduction SARS-CoV-2 is the virus that caused the COVID-19 pandemic and its devastating effects on global
Liver Biopsies Beyond Histological Diagnosis: Ex-vivo Culturing and Precision Cut Slices for Precision Pharmacology
The Liver: Overview, Histology and Pathology The liver (Fig. 1) is the largest organ in the
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