Publications

Cell Lineage-dependent Chiral Actomyosin Flows Drive Cellular Rearrangements In Early C. elegans Development

Early cell divisions of the AB lineage, but not of the P/EMS lineage, undergo chiral counter-rotating actomyosin flows

Abstract

Proper positioning of cells is essential for many aspects of development. Daughter cell positions can be specified via orienting the cell division axis during cytokinesis. Rotatory actomyosin flows during division have been implied in specifying and reorienting the cell division axis, but how general such reorientation events are, and how they are controlled, remains unclear. We followed the first nine divisions of Caenorhabditis elegans embryo development and demonstrate that chiral counter-rotating flows arise systematically in early AB lineage, but not in early P/EMS lineage cell divisions. Combining our experiments with thin film active chiral fluid theory we identify a mechanism by which chiral counter-rotating actomyosin flows arise in the AB lineage only, and show that they drive lineage-specific spindle skew and cell reorientation events. In conclusion, our work sheds light on the physical processes that underlie chiral morphogenesis in early development.

Source

Pimpale, L. G., Middelkoop, T. C., Mietke, A., & Grill, S. W. (2020). Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development. ELife, 9. https://doi.org/10.7554/elife.54930

Related Posts

Cell Lineage-dependent Chiral Actomyosin Flows Drive Cellular Rea...
Early cell divisions of the AB lineage, but not of the P/EMS lineage, undergo chiral counter-rotating actomyosin flows Abstract Proper posit...
Read more
BUB-1 Promotes Amphitelic Chromosome Biorientation Via Multiple A...
Introduction In the publication Edwards F. et al. (eLife 2018), the authors decipher several molecular mechanisms governing chromosome seg...
Read more
C. elegans – The Need Of Controlling Temperature...
C. elegans as a major model organism in biology ? Since C. elegans starts to be used as a model organism more than 20.000 publications cov...
Read more

get in touch

Get the best insights about Cherry Biotech by Email Let’s stay in touch!