Scientific notes

Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium

Immune Checkpoint Modulators as an emerging therapy

Through this paper, Kim and colleagues highlight the way that immune checkpoint modulators are exploited by tumor cells to decrease immune activation and antigen recognition. Therefore, these checkpoint modulators can also be a powerful tool to improve cancer therapy. It is a non-specific strategy that consists of a generalized activation of the immune system that can be combined with chemotherapy and/or radiation therapy. Indeed, monoclonal antibodies such as anti-CTLA-4 (ipilimumab) and anti-PD-1 (nivolumab), can be used to target checkpoint inhibitors for a therapeutic blockade. Both are already in phase 4 of clinical development but there are many other targets known as LAG-3, TIM-3, KIR, and GITR which are in phase 1 or 2.

Check Point modulator validation system dedicated system to cell-cell interactions follow-up

How to culture vascularized & immunocompetent 3D models in a standard Multiwell

Summary

Immune checkpoints have come to the forefront of cancer therapies as a powerful and promising strategy to stimulate antitumor T cell activity. Results from recent preclinical and clinical studies demonstrate how checkpoint inhibition can be utilized to prevent tumor immune evasion and both local and systemic immune suppression. This review encompasses the key immune checkpoints that have been found to play a role in tumorigenesis and, more specifically, gliomagenesis. The review will provide an overview of the existing preclinical and clinical data, antitumor efficacy, and clinical applications for each checkpoint with respect to GBM, as well as a summary of combination therapies with chemotherapy and radiation.

References

Related Posts

Diagram showing two-way interaction between tumor cells and adipose tissue microenvironment, highlighting metabolic, inflammatory, and endocrine signaling in cancer progression.
How the adipose tissue microenvironment shapes cancer therapy out...
The interplay between adipose tissue and therapeutic efficacy is now recognised as a major determinant of clinical response [1]. Adipose ti...
Read more
cherry-biotech_3D_breast_cancer_cells
2D vs 3D breast cancer models: Patient‑derived organoids for tu...
3D breast cancer models are rapidly redefining how we investigate the world’s deadliest malignancy in women, exposing biological complexit...
Read more
Immuno-oncology Trial Endpoints: Capturing Meaningful Activity...
Introduction In this paper, Anagnostou and colleagues “discuss endpoints used in I-O trials to date and potential optimal endpoints for f...
Read more

get in touch

Get the best insights about Cherry Biotech by Email Let’s stay in touch!
As part of our commercial prospecting, we may need to process your personal data. For more information, please consult our Privacy Policy