Scientific notes

Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases

Introduction

MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal experimentation and improve preclinical toxicity assessments to an intriguing stepping stone in efforts to replicate our own biology. The future premise of MPS is clear: multicellular tissue models that are true to our own physiology would allow us to conduct expensive clinical trials at a fraction of the cost.

Reduce the use of animals in experiments, serve as a surrogate for exploring the dangers of new environments such as deep space, and provide insight into the laws governing tissue homeostasis, repair, and the emergence of complex diseases, to name a few. While this may sound like a pipe dream, it is a reality that the field is gradually achieving.

How to culture vascularized & immunocompetent 3D models in a standard Multiwell

Abstract

The author states that “Metabolic and inflammatory disorders such as autoimmune and neurodegenerative diseases are increasing at alarming rates. Many of these are not tissue-specific occurrences but complex, systemic pathologies of unknown origin for which no cure exists.

Such complexity obscures causal relationships among factors regulating disease progression. Emerging technologies mimicking human physiology, such as microphysiological systems (MPSs), offer new possibilities to provide clarity in systemic metabolic and inflammatory diseases.

Controlled interaction of multiple MPSs and the scalability of biological complexity in MPSs, supported by continuous multiomic monitoring, might hold the key to identifying novel relationships between interorgan crosstalk, metabolism, and immunity.

In this perspective, I aim to discuss the current state of modeling multiorgan physiology and evaluate current opportunities and challenges.”

References

Trapecar M. Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases. FEBS Lett. 2021 Dec 18. doi: 10.1002/1873-3468.14260. Epub ahead of print. PMID: 34923635.

Related Posts

High-resolution photo of a microfluidic organ-on-chip under a microscope, USB-linked to a laptop that displays breast-cancer imaging and analytics graphs.
Organoid and artificial intelligence in breast cancer research...
Introduction Organoid and artificial intelligence approaches are central to the FDA’s roadmap for reducing animal use in preclinical safet...
Read more
Sentinel Lymph Nodes (SLN) Biopsies: Clinical Aspects...
Context The lymphatic system is approximately omnipresent in the human body and present in most human tissues excluding cartilage, eye lens,...
Read more
Tumor_targeting
3D cell culture and anticancer drug testing...
Efficacity and toxicity of candidate anticancer drugs on 3D cell culture model has been much lower than on 2D cell culture models over the p...
Read more

get in touch

Get the best insights about Cherry Biotech by Email Let’s stay in touch!
As part of our commercial prospecting, we may need to process your personal data. For more information, please consult our Privacy Policy