How the adipose tissue microenvironment shapes cancer therapy outcomes
The interplay between adipose tissue and therapeutic efficacy is now recognised as a major determinant of clinical
Scientific Notes
Are spheroids recapitulating basic physiology of human organs?
Spheroids, as a good universal organ model ? Recent advances in bioengineering of cells, tissue coupled
Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases
Introduction MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal experimentation and improve preclinical
Introduction to the human body
The human body: systems, organs, and main functions The human body is composed of several different
Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going?
Introduction Melanoma is clearly a complex disease with a high degree of heterogeneity and adaptability. Melanoma
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
Introduction The researchers created a microfluidic organ-on-chip solution with integrated electrochemical microsensor arrays enabling compartmentalized matrix-based organoid culture
A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation
Introduction Animal models and two-dimensional (2D) cell cultures frequently fail to replicate human drug metabolism and liver
Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems
Introduction Adipose Tissue is very versatile and essential for studies related to Obesity and Diabetes, however, the high buoyancy, fragility,
A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept
Introduction The state of the art for tissues-on-chips using skin cells had been lacking for a long time
Facilitating implementation of organs-on-chips by open platform technology
Introduction Many Organ-on-Chip platforms are still not robust for all cell types, are not reproducible from experiment to
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