Scientific notes

Imaging of mitochondria positioning on microtubule using fast temperature regulation

Abstract of mmb1p Binds Mitochondria to Dynamic Microtubules

 Mitochondria form a dynamic tubular network within the cell. Proper mitochondria movement and distribution are critical for their localized function in cell metabolism, growth, and survival. In mammalian cells, mechanisms of mitochondria positioning appear dependent on the microtubule cytoskeleton, with kinesin or dynein motors carrying mitochondria as cargos and distributing them throughout the microtubule network. Interestingly, the timescale of microtubule dynamics occurs in seconds, and the timescale of mitochondria distribution occurs in minutes. How does the cell couple these two time constants?

Video extracted from the publication. 

How to culture vascularized & immunocompetent 3D models in a standard Multiwell

References

https://www.sciencedirect.com/science/article/pii/S0960982211007822Chuanhai Fu, Deeptee Jain, Judite Costa, Guilhem Velve-Casquillas, Phong T. Tran, mmb1p Binds Mitochondria to Dynamic Microtubules, Current Biology, Volume 21, Issue 17, 2011, Pages 1431-1439,

Related Posts

Organ-on-a-Chip: A New Paradigm for Drug Development...
Introduction Organ-on-a-Chip is a potential, multidisciplinary method for in-vitro modeling of disease, drug screening, and precision medic...
Read more
Semi-realistic medical illustration of a human liver with fatty deposits, showing yellow lipid droplets distributed throughout the tissue, representing hepatic steatosis (fatty liver disease).
Organoids for Lipid Metabolism: Organoid and Organ-on-Chip Models...
Understanding how the body processes fats is central to tackling obesity, type 2 diabetes, and fatty liver disease. Yet, traditional models ...
Read more
Advanced Models of Human Muscle Differentiation: 3D Cultures, Org...
Introduction The organization and function of living muscle tissues cannot be fully recapitulated by typical two-dimensional (2D) culture me...
Read more

get in touch

Get the best insights about Cherry Biotech by Email Let’s stay in touch!
As part of our commercial prospecting, we may need to process your personal data. For more information, please consult our Privacy Policy